Chromosomal abnormalities in azoospermic and non-azoospermic infertile men: numbers needed to be screened to prevent adverse pregnancy outcomes

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Chromosomal abnormalities in azoospermic and non-azoospermic infertile men: numbers needed to be screened to prevent adverse pregnancy outcomes.

STUDY QUESTION How many infertile men who wish to conceive need to be screened for chromosomal abnormalities to prevent one miscarriage or the birth of one child with congenital anomalies (CAs)? SUMMARY ANSWER In azoospermic men, the prevalence of chromosomal abnormalities is 15.2% and the number needed to be screened (NNS; minimum-maximum estimate) for a miscarriage is 80-88 and for a child ...

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Chromosomal Aneuploidy in Azoospermic Men

The aim of this study was to estimate the prevalence of chromosome abnormalities in patients with azoospermia, in our material. Preoperative evaluation included routine andrological investigations with 2 semen analysis, ultrasound, hormonal and genetic examinations. In the last three years, 73 biopsies were performed for testicular sperm extraction in 71 patients. Non-obstructive azoospermia wa...

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chromosomal anomalies in infertile azoospermic and oligospermic men

in this study, chromosome analyses were performed on 70 infertile azoospermic and oligospermic (<20 million/ml) men, and also cultures of peripheral blood lymphocytes by high resolution banding method were analysed as well. it is revealed 8 (11.43 percent) men with chromosomal abnormality. there were 31.4 percent patients with azoospermia and 68.6 percent with oligospermia from several thousand...

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P-194: SEPT12-G800A Polymorphism in Azoospermic Infertile Men Referred to Royan Institute

Background: SEPTINS belong to a family of polymerizing GTP-binding proteins that are required for many cellular functions, such as vesicular trafficking, mitosis, membrane compartmentalization and cytoskeletal remodeling. Among all SEPTIN genes, SEPT12 is dominantly expressed in testis tissue of adults, known as an essential annulus component of mature sperm. Therefore, it is hypothesized that ...

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Varicocelectomy May Improve Results for Sperm Retrieval and Pregnancy Rate in Non-Obstructive Azoospermic Men

Objective Improvement in sperm density and motility after varicocelectomy have been widely reported for men with oligoasthenoteratospermia (OAT),However the value of varicocelectomy in azoospermic men remain controversial.In this study we have evaluated the outcome of microsurgical varicocelectomy in nonobstructive azoospermic (NOA) men with clinical varicocele in five years in royan institute....

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ژورنال

عنوان ژورنال: Human Reproduction

سال: 2012

ISSN: 1460-2350,0268-1161

DOI: 10.1093/humrep/des222